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SCHEMBL4734816

SCHEMBL4734816

CN(C)c1cccc(C(=O)N2CCC(NS(=O)(=O)c3ccc(-c4ccccc4)cc3C(F)(F)F)CC2)c1

nearest known ligand 0.59

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ SFRP1 Q8N474 15/20 0.59
▸ CACNA1B Q00975 1/20 0.52
▸ WNT3 P56703 2/20 0.49
▸ ABL1 P00519 1/20 0.47
▸ BCR P11274 1/20 0.47
▸ CCR8 P51685 1/20 0.47
▸ HSD11B1 P28845 1/20 0.46
▸ SYK P43405 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4732857 0.91 SFRP1 (0.71) SFRP1WNT3CCR8
SCHEMBL4736194 0.88 SFRP1 (0.57) SFRP1CACNA1BWNT3CCR8HSD11B1
SCHEMBL4734370 0.87 SFRP1 (0.57) SFRP1WNT3
SCHEMBL4731851 0.86 SFRP1 (0.62) SFRP1WNT3CCR8
SCHEMBL4733669 0.85 SFRP1 (0.56) SFRP1WNT3CCR8
SCHEMBL4734490 0.84 SFRP1 (0.73) SFRP1WNT3
SCHEMBL4785270 0.84 SFRP1 (0.60) SFRP1WNT3
SCHEMBL4781291 0.84 SFRP1 (0.52) SFRP1WNT3
SCHEMBL4735053 0.83 SFRP1 (0.57) SFRP1WNT3
SCHEMBL4734894 0.83 SFRP1 (0.58) SFRP1WNT3CCR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 — — WO claimed
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 — — WO disclosed