Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4799653 | 0.99 | PARG (0.35) | PARGALOX5APFEN1PDE4APDE4B | |
| SCHEMBL4731973 | 0.86 | HPGD (0.39) | ALOX5APFEN1TDP1SFRP1 | |
| SCHEMBL4785987 | 0.86 | PARG (0.38) | PARGALOX5APFEN1PDE4APDE4B | |
| SCHEMBL4731773 | 0.84 | PARG (0.37) | PARGALOX5APFEN1PDE4APDE4B | |
| SCHEMBL4734109 | 0.82 | MEN1 (0.43) | TDP1TSHRHTTSFRP1 | |
| SCHEMBL4798309 | 0.81 | MEN1 (0.44) | — | |
| SCHEMBL4731748 | 0.80 | POLB (0.45) | TSHRHTTSFRP1 | |
| SCHEMBL4733147 | 0.79 | POLB (0.44) | TSHRHTTSFRP1 | |
| SCHEMBL4731932 | 0.79 | KMT2A (0.37) | ALOX5APFEN1HTT | |
| SCHEMBL4730155 | 0.79 | CNR2 (0.39) | TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |