Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731773 | 0.88 | PARG (0.37) | PARGPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4734831 | 0.86 | PARG (0.36) | PARGPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4799653 | 0.85 | PARG (0.35) | PARGPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4731926 | 0.79 | POLB (0.47) | TDP1SFRP1HTTPOLB | |
| SCHEMBL4733929 | 0.78 | PARG (0.39) | PARGPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4732817 | 0.76 | CNR2 (0.39) | MEN1KMT2ALMNAHTT | |
| SCHEMBL4732278 | 0.76 | ALDH1A1 (0.33) | TDP1MEN1KMT2A | |
| SCHEMBL4733900 | 0.74 | ALDH1A1 (0.41) | FEN1TDP1SFRP1MEN1KMT2A | |
| SCHEMBL4736205 | 0.72 | HTT (0.35) | MEN1KMT2ALMNAHTTTP53 | |
| SCHEMBL4733960 | 0.72 | PIK3CD (0.36) | ALOX5APFEN1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |