Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731748 | 0.99 | POLB (0.45) | POLBTSHRALDH1A1PRMT5WDR77 | |
| SCHEMBL4734109 | 0.90 | MEN1 (0.43) | POLBTSHRALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4731926 | 0.87 | POLB (0.47) | POLBTSHRALDH1A1PRMT5WDR77 | |
| SCHEMBL4734712 | 0.85 | POLB (0.46) | POLBTSHRALDH1A1PRMT5WDR77 | |
| SCHEMBL4731973 | 0.85 | HPGD (0.39) | POLBALDH1A1SMN1; SMN2SFRP1NPSR1 | |
| SCHEMBL4798309 | 0.84 | MEN1 (0.44) | PRMT5WDR77 | |
| SCHEMBL4729666 | 0.83 | MEN1 (0.44) | PRMT5WDR77 | |
| SCHEMBL4731938 | 0.82 | POLB (0.45) | POLBTSHRALDH1A1PRMT5WDR77 | |
| SCHEMBL4799653 | 0.81 | PARG (0.35) | TSHRHTTSFRP1 | |
| SCHEMBL4734831 | 0.79 | PARG (0.36) | TSHRHTTSFRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |