Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.39 |
| ▸ | USP2 | O75604 | 8/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 6/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | VNN1 | O95497 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735502 | 0.77 | PTGDR (0.41) | CLK4DYRK1APTGDRCYP3A4USP2 | |
| SCHEMBL4906480 | 0.75 | BACE1 (0.42) | CLK4DYRK1APTGDRCYP3A4USP2 | |
| SCHEMBL4736456 | 0.68 | CLK4 (0.49) | CLK4DYRK1APTGDRCYP3A4USP2 | |
| SCHEMBL4781470 | 0.66 | BACE1 (0.40) | CLK4DYRK1ACYP3A4USP2CYP1A2 | |
| SCHEMBL7560589 | 0.65 | BACE1 (0.44) | CLK4CYP3A4CYP1A2CYP2C19HSD17B10 | |
| SCHEMBL4913733 | 0.64 | BACE1 (0.43) | CYP3A4CYP1A2CYP2C19HSD17B10PGR | |
| SCHEMBL5067185 | 0.64 | CA2 (0.42) | ALDH1A1LMNATP53PGR | |
| SCHEMBL28524044 | 0.64 | MEN1 (0.54) | CLK4DYRK1AALDH1A1TSHRMEN1 | |
| SCHEMBL9792939 | 0.64 | CLK4 (0.62) | CLK4CYP3A4USP2CYP1A2CYP2C19 | |
| SCHEMBL8481744 | 0.63 | ABL1 (0.58) | CLK4DYRK1APTGDRCYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076046-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |