Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734186 | 0.86 | GRM1 (0.45) | HTTGAATSHRGRM1MAPT | |
| SCHEMBL4786765 | 0.85 | GAA (0.51) | HTTGAATSHRGRM1MAPT | |
| SCHEMBL3824769 | 0.83 | CFTR (0.55) | HTTTSHRGRM1GRIA2GRIN1 | |
| SCHEMBL3063987 | 0.81 | GRIN1 (0.43) | GRM1GRIA2GRIN1GRIN2AMEN1 | |
| SCHEMBL4737103 | 0.79 | GAA (0.43) | HTTGAATSHRGRM1MAPT | |
| SCHEMBL4737959 | 0.79 | HTT (0.46) | HTTGAATSHRNPSR1GFER | |
| SCHEMBL3065115 | 0.78 | GRIN1 (0.42) | GRM1GRIA2GRIN1GRIN2ANPC1 | |
| SCHEMBL4735442 | 0.77 | AR (0.43) | HTTGAATSHRMAPTNPC1 | |
| SCHEMBL4737675 | 0.76 | GAA (0.42) | HTTGAATSHRGRM1MAPT | |
| SCHEMBL4738953 | 0.76 | GAA (0.40) | HTTGAATSHRGRM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |