Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.55 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.45 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | DNM1L | O00429 | 1/20 | 0.38 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3826994 | 0.87 | CFTR (0.46) | CFTRGRM1PDK1KMT2ABCHE | |
| SCHEMBL3063987 | 0.83 | GRIN1 (0.43) | GRM1KMT2AGRIA2GRIN1GRIN2A | |
| SCHEMBL4735528 | 0.83 | HTT (0.50) | GRM1KMT2AGRIA2GRIN1GRIN2A | |
| SCHEMBL3065115 | 0.81 | GRIN1 (0.42) | GRM1GRIA2GRIN1GRIN2A | |
| SCHEMBL3825536 | 0.79 | MAPK14 (0.47) | GRM1PDK1KMT2ALMNAMAPT | |
| SCHEMBL3824906 | 0.77 | DNM1L (0.45) | KMT2AALDH1A1MAPTDNM1L | |
| Hydrochloric Acid SCHEMBL3829987 | 0.76 | DNM1L (0.44) | ALDH1A1MAPTDNM1L | |
| SCHEMBL4738810 | 0.76 | GRM1 (0.39) | CFTRGRM1PDK1KMT2AALDH1A1 | |
| SCHEMBL3821700 | 0.76 | CNR2 (0.49) | CNR2CNR1PDK1BCL2A1 | |
| SCHEMBL3826390 | 0.75 | MAPT (0.50) | ALDH1A1LMNAMAPTHTTDNM1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097379-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-09 | — | — | EP | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |