Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 18/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.52 |
| ▸ | WNT3 | P56703 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735724 | 0.89 | SFRP1 (0.52) | SFRP1CYP3A4CYP2C9SLC9A1CYP2C19 | |
| SCHEMBL4736208 | 0.86 | SFRP1 (0.51) | SFRP1SLC22A12WNT3 | |
| SCHEMBL4736341 | 0.82 | SFRP1 (0.61) | SFRP1WNT3 | |
| SCHEMBL4734225 | 0.81 | SFRP1 (0.64) | SFRP1WNT3 | |
| SCHEMBL4732795 | 0.81 | SFRP1 (0.80) | SFRP1SLC22A12WNT3 | |
| SCHEMBL4733995 | 0.80 | SFRP1 (0.63) | SFRP1WNT3 | |
| SCHEMBL4736315 | 0.80 | SFRP1 (0.61) | SFRP1WNT3 | |
| SCHEMBL4733578 | 0.79 | SFRP1 (0.60) | SFRP1WNT3 | |
| SCHEMBL4731312 | 0.79 | SFRP1 (0.52) | SFRP1CYP3A4CYP2C9SLC9A1CYP2C19 | |
| SCHEMBL4732035 | 0.78 | SFRP1 (0.60) | SFRP1WNT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |