Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 2/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17336011 | 0.87 | HSP90AA1 (0.50) | GAAHSP90AB1HSP90AA1 | |
| SCHEMBL4731523 | 0.80 | HSP90AA1 (0.40) | HSP90AB1HSP90AA1DHFR | |
| SCHEMBL4736448 | 0.80 | GAA (0.32) | GAAKMOMEN1ALDH1A1HPGD | |
| SCHEMBL14209035 | 0.79 | HSP90AB1 (0.49) | HSP90AB1HSP90AA1DHFR | |
| SCHEMBL17349447 | 0.79 | HSP90AA1 (0.39) | HSP90AB1HSP90AA1DHFRMEN1ALDH1A1 | |
| SCHEMBL4736451 | 0.79 | L3MBTL1 (0.33) | GAAMEN1ALDH1A1KMT2A | |
| SCHEMBL14208261 | 0.79 | L3MBTL1 (0.33) | GAAMEN1ALDH1A1KMT2A | |
| SCHEMBL14207911 | 0.78 | ADORA2A (0.34) | HSP90AB1HSP90AA1HPGD | |
| SCHEMBL4735379 | 0.78 | HSP90AB1 (0.51) | HSP90AB1HSP90AA1DHFR | |
| SCHEMBL4732878 | 0.77 | HSP90AA1 (0.41) | HSP90AB1HSP90AA1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008059368-A2 | FUSED 2-AMINO PYRIMIDINE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008059368-A2 | FUSED 2-AMINO PYRIMIDINE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | disclosed |