Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733657 | 0.88 | CHEK1 (0.52) | CHEK1NPC1RAB9AKMT2AHPGD | |
| SCHEMBL4739602 | 0.79 | RAB9A (0.54) | CHEK1NPC1RAB9AKMT2AHPGD | |
| SCHEMBL4734482 | 0.78 | RAB9A (0.58) | CHEK1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL11589312 | 0.75 | NPC1 (0.48) | CHEK1NPC1RAB9AKMT2AHPGD | |
| SCHEMBL11589491 | 0.75 | HPGD (0.48) | CHEK1NPC1RAB9AKMT2AHPGD | |
| SCHEMBL4762048 | 0.72 | CHEK1 (0.41) | CHEK1NPC1RAB9AKMT2AHPGD | |
| SCHEMBL9422086 | 0.71 | NPC1 (0.80) | NPC1RAB9AKMT2AHPGDTSHR | |
| SCHEMBL13996099 | 0.70 | NPC1 (0.49) | CHEK1NPC1RAB9AKMT2AHPGD | |
| SCHEMBL3068359 | 0.70 | LMNA (0.52) | CHEK1NPC1RAB9AKMT2AHPGD | |
| SCHEMBL168291 | 0.69 | TDP1 (0.67) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |