Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CLK3 | P49761 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4683088 | 0.86 | GRM5 (0.37) | GRM5MAPKAPK2PARP10PARP11CYP1A2 | |
| SCHEMBL4679372 | 0.84 | GRM5 (0.40) | GRM5MAPKAPK2CYP1A2 | |
| SCHEMBL4686152 | 0.83 | GRM5 (0.36) | GRM5MAPKAPK2HSP90AA1 | |
| SCHEMBL8248263 | 0.77 | GRM5 (0.40) | GRM5 | |
| SCHEMBL4686336 | 0.77 | CYP11B2 (0.40) | GRM5 | |
| SCHEMBL4737979 | 0.76 | GRM5 (0.38) | GRM5MAPKAPK2PARP10PARP11HSP90AA1 | |
| SCHEMBL4686098 | 0.74 | GRM5 (0.44) | GRM5CYP1A2 | |
| SCHEMBL4686025 | 0.74 | GRM5 (0.40) | GRM5HSP90AA1HSP90AB1 | |
| SCHEMBL4684269 | 0.74 | GRM5 (0.40) | GRM5CYP1A2 | |
| SCHEMBL4684250 | 0.73 | GRM5 (0.40) | GRM5HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943247-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-07-16 | — | — | EP | claimed |
| WO-2007023245-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | claimed |