Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | AKT2 | P31751 | 2/20 | 0.32 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4684250 | 0.94 | GRM5 (0.40) | GRM5ALDH1A1POLBGFERBRD4 | |
| SCHEMBL4686098 | 0.85 | GRM5 (0.44) | GRM5ALDH1A1BRD4CYP11B2CHEK1 | |
| SCHEMBL4683088 | 0.85 | GRM5 (0.37) | GRM5GSK3B | |
| SCHEMBL6103021 | 0.83 | GRM5 (0.40) | GRM5ALDH1A1POLBGFERBRD4 | |
| SCHEMBL4679372 | 0.82 | GRM5 (0.40) | GRM5ALDH1A1TSHRMAPTLMNA | |
| SCHEMBL4686152 | 0.80 | GRM5 (0.36) | GRM5CYP11B2 | |
| SCHEMBL4686025 | 0.79 | GRM5 (0.40) | GRM5AKT1AKT2CYP11B2 | |
| SCHEMBL4736631 | 0.77 | GRM5 (0.34) | GRM5 | |
| SCHEMBL4686336 | 0.76 | CYP11B2 (0.40) | GRM5CYP11B2 | |
| SCHEMBL4684400 | 0.74 | CYP11B2 (0.40) | GRM5CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023245-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | disclosed |