Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 7/20 | 0.41 |
| ▸ | PGR | P06401 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CCR1 | P32246 | 3/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733246 | 0.70 | NR3C1 (0.49) | NR3C1PGRARSMO | |
| SCHEMBL14144150 | 0.68 | NR3C1 (0.49) | NR3C1PGRCCR1ARSMO | |
| SCHEMBL4737732 | 0.67 | SMO (0.44) | NR3C1PGRARSMO | |
| SCHEMBL14144304 | 0.65 | NR3C1 (0.50) | NR3C1PGRCCR1SMO | |
| SCHEMBL4552036 | 0.64 | NR3C1 (0.53) | NR3C1PGRARSMO | |
| SCHEMBL14144337 | 0.63 | NR3C1 (0.61) | NR3C1PGRARCYP3A4 | |
| SCHEMBL441369 | 0.63 | NR3C1 (0.57) | NR3C1PGR | |
| SCHEMBL26495603 | 0.63 | LRRK2 (0.41) | NR3C1PGRCCR1ARSMO | |
| SCHEMBL3236916 | 0.62 | MAPT (0.80) | POLBSMN1; SMN2GAAMAPTALDH1A1 | |
| SCHEMBL24153234 | 0.62 | LRRK2 (0.43) | NR3C1PGRCCR1ARKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079073-A1 | INDAZOLYL SULPHONAMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-07-03 | — | — | WO | disclosed |