Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | CCKAR | P32238 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.34 |
| ▸ | LATS1 | O95835 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11908027 | 0.91 | SLC2A1 (0.41) | CYP11B1CYP11B2PTGDR2CYP2A6CYP2C9 | |
| SCHEMBL1560920 | 0.89 | CYP11B1 (0.38) | CYP11B1CYP11B2GBA1CYP2A6CYP3A4 | |
| SCHEMBL2218828 | 0.85 | PIM1 (0.41) | CYP11B1CYP11B2GBA1PTGDR2CYP2A6 | |
| SCHEMBL1561368 | 0.84 | POLB (0.36) | CYP11B1CYP11B2GBA1PTGDR2CYP2A6 | |
| SCHEMBL473708 | 0.84 | CYP2A6 (0.40) | CYP11B1CYP11B2GBA1PTGDR2CYP2A6 | |
| SCHEMBL2220367 | 0.84 | CYP2A6 (0.40) | CYP11B1CYP11B2GBA1PTGDR2CYP2A6 | |
| SCHEMBL1560996 | 0.83 | CTPS1 (0.40) | CYP11B1CYP11B2CKS1BSKP2 | |
| SCHEMBL1560999 | 0.83 | ABCB1 (0.37) | CYP11B1CYP11B2PTGDR2CYP2A6PIM1 | |
| SCHEMBL2218482 | 0.82 | CYP2A6 (0.38) | CYP11B1CYP11B2GBA1PTGDR2CYP2A6 | |
| SCHEMBL1559921 | 0.80 | ABCB1 (0.41) | CYP11B1CYP11B2CKS1BSKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411389-A2 | 9H-PYRROLO[2,3-B: 5,4-C']DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010109084-A2 | 9H-PYRROLO[2,3-B: 5,4-C'] DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | disclosed |