Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | SNCA | P37840 | 2/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736806 | 1.00 | ESR1 (0.53) | ESR1ESR2CYP1B1DPP4CXCL12 | |
| SCHEMBL4741756 | 0.79 | GABRA3 (0.48) | CYP1B1MAPTCHRNA7CAPN1CTSL | |
| SCHEMBL4741758 | 0.79 | GABRA3 (0.48) | CYP1B1MAPTCHRNA7CAPN1CTSL | |
| SCHEMBL4785911 | 0.79 | DPP4 (0.55) | ESR1ESR2CYP1B1DPP4CXCL12 | |
| SCHEMBL4785916 | 0.79 | DPP4 (0.55) | ESR1ESR2CYP1B1DPP4CXCL12 | |
| SCHEMBL29837090 | 0.76 | MAPT (0.71) | ESR1ESR2CYP1B1MAPTCHRNA7 | |
| SCHEMBL21647128 | 0.76 | MAPT (0.71) | ESR1ESR2CYP1B1MAPTCHRNA7 | |
| SCHEMBL21647129 | 0.76 | MAPT (0.71) | ESR1ESR2CYP1B1MAPTCHRNA7 | |
| SCHEMBL363885 | 0.76 | CYP1B1 (0.51) | ESR1ESR2CYP1B1DPP4MAPT | |
| SCHEMBL16047829 | 0.75 | MIF (0.56) | ESR1ESR2DPP4MAPTSNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087365-A2 | SUBSTITUTED 1, 3-DIPHENYLPROPANE DERIVATIVES, PREPARATIONS AND USES OF SAME | GENFIT (FR) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008087365-A2 | SUBSTITUTED 1, 3-DIPHENYLPROPANE DERIVATIVES, PREPARATIONS AND USES OF SAME | GENFIT (FR) | 2008-07-24 | — | — | WO | disclosed |