Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.37 |
| ▸ | MTOR | P42345 | 3/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4741753 | 0.92 | CCR2 (0.42) | CCR2PIK3CDPIK3CAMTORBRAF | |
| SCHEMBL4740771 | 0.92 | CCR2 (0.38) | CCR2PIK3CDPIK3CAMTORBRAF | |
| SCHEMBL4787518 | 0.92 | CCR2 (0.41) | CCR2PIK3CDPIK3CAMTORBRAF | |
| SCHEMBL4739014 | 0.90 | PI4KA (0.42) | CCR2PIK3CDPIK3CAMTORBRAF | |
| SCHEMBL4785896 | 0.89 | ADORA2A (0.41) | CCR2PIK3CDPIK3CAMTORPI4KA | |
| SCHEMBL4787508 | 0.88 | PIK3CD (0.44) | CCR2PIK3CDPIK3CAMTORBRAF | |
| SCHEMBL4736847 | 0.88 | TP53 (0.39) | CCR2PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL4740778 | 0.87 | CCR2 (0.39) | CCR2PIK3CDPIK3CAMTORBRAF | |
| SCHEMBL4785904 | 0.87 | PIK3CA (0.40) | CCR2PIK3CDPIK3CAMTORBRAF | |
| SCHEMBL4741146 | 0.87 | PIK3C3 (0.40) | CCR2PIK3CDPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |