Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.80 |
| ▸ | MAPT | P10636 | 5/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.72 |
| ▸ | HPGD | P15428 | 7/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8202423 | 0.93 | TP53 (0.77) | TP53MAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL1718453 | 0.91 | HPGD (0.80) | TP53MAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL8191835 | 0.91 | TP53 (0.77) | TP53MAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL4207359 | 0.88 | TP53 (0.84) | TP53MAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL4211257 | 0.88 | POLB (0.79) | TP53MAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL1718691 | 0.87 | TP53 (0.68) | TP53MAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL8199380 | 0.86 | MAPT (1.00) | TP53MAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL1718971 | 0.85 | TP53 (0.68) | TP53MAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL4731862 | 0.84 | KDM4E (0.80) | TP53MAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL4734233 | 0.84 | MAPT (0.75) | TP53MAPTLMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008056176-A1 | PYRAZOLOPYRIMIDINES AS PHOSPHODIESTERASE INHIBITORS | SCOTTISH BIOMEDICAL LIMITED (GB) | 2008-05-15 | — | — | WO | disclosed |