Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.75 |
| ▸ | RAB9A | P51151 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | NPC1 | O15118 | 1/20 | 0.75 |
| ▸ | TP53 | P04637 | 5/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3784675 | 0.86 | RAB9A (1.00) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4737183 | 0.84 | TP53 (0.80) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8202423 | 0.83 | TP53 (0.77) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1718453 | 0.81 | HPGD (0.80) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8191835 | 0.81 | TP53 (0.77) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8199380 | 0.80 | MAPT (1.00) | MAPTALDH1A1SMN1; SMN2TP53LMNA | |
| SCHEMBL1718398 | 0.78 | MAPT (0.75) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1718691 | 0.77 | TP53 (0.68) | MAPTALDH1A1SMN1; SMN2TP53LMNA | |
| SCHEMBL8192027 | 0.77 | TP53 (0.65) | MAPTALDH1A1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL1718971 | 0.76 | TP53 (0.68) | MAPTALDH1A1RAB9ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008056176-A1 | PYRAZOLOPYRIMIDINES AS PHOSPHODIESTERASE INHIBITORS | SCOTTISH BIOMEDICAL LIMITED (GB) | 2008-05-15 | — | — | WO | disclosed |
| WO-2008056176-A1 | PYRAZOLOPYRIMIDINES AS PHOSPHODIESTERASE INHIBITORS | SCOTTISH BIOMEDICAL LIMITED (GB) | 2008-05-15 | — | — | WO | disclosed |