Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 13/20 | 0.54 |
| ▸ | PPARD | Q03181 | 11/20 | 0.52 |
| ▸ | PPARG | P37231 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737309 | 1.00 | PPARA (0.54) | PPARAPPARDPPARGALDH1A1MAPT | |
| SCHEMBL14146399 | 0.91 | MAPT (0.44) | PPARAPPARDPPARGALDH1A1MAPT | |
| SCHEMBL4737314 | 0.86 | PPARD (0.53) | PPARAPPARDPPARGALDH1A1NPC1 | |
| SCHEMBL4737311 | 0.86 | PPARD (0.53) | PPARAPPARDPPARGALDH1A1NPC1 | |
| SCHEMBL14146448 | 0.86 | PPARD (0.53) | PPARAPPARDPPARGALDH1A1NPC1 | |
| SCHEMBL4740490 | 0.84 | ALDH1A1 (0.52) | PPARAPPARDPPARGALDH1A1MAPT | |
| SCHEMBL4740506 | 0.84 | ALDH1A1 (0.52) | PPARAPPARDPPARGALDH1A1MAPT | |
| SCHEMBL14146337 | 0.83 | ALDH1A1 (0.45) | PPARAPPARDPPARGALDH1A1MAPT | |
| SCHEMBL4737608 | 0.80 | TNFRSF1A (0.55) | — | |
| SCHEMBL4787159 | 0.80 | TNFRSF1A (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087367-A2 | SUBSTITUTED (PHENYLTHIAZOLYL)-PHENYL-PROPAN-1-ONE AND (PHENYLOXAZODYL)-PHENYL-PROPAN-1-ONE DERIVATIVES, PREPARATIONS AND USES OF SAME | GENFIT (FR) | 2008-07-24 | — | — | WO | claimed |
| WO-2008087367-A2 | SUBSTITUTED (PHENYLTHIAZOLYL)-PHENYL-PROPAN-1-ONE AND (PHENYLOXAZODYL)-PHENYL-PROPAN-1-ONE DERIVATIVES, PREPARATIONS AND USES OF SAME | GENFIT (FR) | 2008-07-24 | — | — | WO | disclosed |