Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4574787 | 0.85 | MEN1 (0.33) | ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL4664618 | 0.77 | KMT2A (0.35) | ALDH1A1GAARAB9AMEN1KMT2A | |
| SCHEMBL4963781 | 0.76 | CTNNB1 (0.35) | KDM4EHSD17B10ALDH1A1GAANPC1 | |
| SCHEMBL4662901 | 0.76 | CXCR2 (0.33) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5138943 | 0.76 | CXCR2 (0.33) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4664643 | 0.76 | CXCR2 (0.33) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4964535 | 0.76 | PDK1 (0.35) | ALDH1A1GAATSHRSMN1; SMN2NPC1 | |
| SCHEMBL4738554 | 0.75 | KDM4E (0.35) | KDM4EHSD17B10ALDH1A1GAANPC1 | |
| SCHEMBL4963749 | 0.75 | GSK3B (0.35) | KDM4EHSD17B10ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL4961335 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071765-A1 | PHARMACEUTICALLY ACTIVE SPIRO-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2008-06-19 | — | — | WO | disclosed |