Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737338 | 0.75 | KDM4E (0.36) | KDM4EALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL4574787 | 0.63 | MEN1 (0.33) | ALDH1A1GAA | |
| SCHEMBL5414028 | 0.58 | KDM4E (0.38) | KDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL3555267 | 0.57 | ALDH1A1 (0.34) | KDM4EALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL5566386 | 0.57 | KDM4E (0.44) | KDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL4777017 | 0.57 | NPC1 (0.34) | KDM4EALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL4592596 | 0.57 | MAP4K1 (0.36) | KDM4EALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL10479354 | 0.57 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10HPGDHTT | |
| SCHEMBL4633246 | 0.56 | LMNA (0.42) | KDM4EALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL5656259 | 0.55 | KDM4A (0.45) | KDM4EALDH1A1HSD17B10GAAPABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071765-A1 | PHARMACEUTICALLY ACTIVE SPIRO-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2008-06-19 | — | — | WO | disclosed |