Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 7/20 | 0.53 |
| ▸ | WNT3 | P56703 | 2/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 2/20 | 0.44 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734668 | 0.88 | SFRP1 (0.53) | SFRP1WNT3ALOX5APFEN1CCR8 | |
| SCHEMBL4732685 | 0.88 | SFRP1 (0.53) | SFRP1WNT3ALOX5APFEN1BRD4 | |
| SCHEMBL4732006 | 0.86 | SFRP1 (0.59) | SFRP1WNT3SCN9ACCR8 | |
| SCHEMBL4734976 | 0.85 | SFRP1 (0.50) | SFRP1WNT3ALOX5APFEN1BRD4 | |
| SCHEMBL4735005 | 0.85 | SFRP1 (0.47) | SFRP1WNT3SCN9A | |
| SCHEMBL4735520 | 0.85 | SFRP1 (0.55) | SFRP1WNT3ALOX5APFEN1CCR8 | |
| SCHEMBL4732944 | 0.84 | SFRP1 (0.62) | SFRP1WNT3ALOX5APFEN1CCR8 | |
| SCHEMBL4733775 | 0.84 | SFRP1 (0.48) | SFRP1WNT3ALOX5APFEN1BRD4 | |
| SCHEMBL4735337 | 0.84 | SFRP1 (0.54) | SFRP1WNT3ALOX5APFEN1CCR8 | |
| SCHEMBL4732022 | 0.84 | SFRP1 (0.54) | SFRP1WNT3ALOX5APFEN1CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |