SCHEMBL4737584

SCHEMBL4737584

Cc1ccc(C(=O)N2CCC(c3ccc(Cl)cc3)CC2)cc1NC(=O)c1ccc(Cl)nc1

nearest known ligand 0.74

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FASN P49327 19/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4736239 0.94 FASN (0.74) FASN
SCHEMBL4735742 0.93 FASN (0.64) FASN
SCHEMBL4737156 0.93 FASN (0.72) FASN
SCHEMBL4731407 0.92 FASN (0.71) FASN
SCHEMBL4784807 0.91 FASN (0.70) FASN
SCHEMBL4731958 0.91 FASN (0.72) FASN
SCHEMBL4733280 0.90 FASN (0.69) FASN
SCHEMBL4733288 0.90 FASN (0.78) FASN
SCHEMBL16802696 0.90 FASN (0.69) FASN
SCHEMBL4735658 0.90 FASN (0.69) FASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008059214-A1 BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS ASTRAZENECA AB (SE) 2008-05-22 WO disclosed