Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260880 | 0.83 | SMO (0.79) | SMOKCNK3KCNK9MEN1KMT2A | |
| SCHEMBL14148493 | 0.82 | KDR (0.45) | SMOKDRGAAFLT1FLT4 | |
| SCHEMBL4787849 | 0.81 | ADCY1 (0.49) | SMOKDRFLT1FLT4PTGS1 | |
| SCHEMBL14148814 | 0.81 | SMO (0.67) | SMOKDRFLT1FLT4SMN1; SMN2 | |
| SCHEMBL14148538 | 0.79 | TP53 (0.57) | SMOKDRMEN1KMT2AFLT1 | |
| SCHEMBL14148519 | 0.79 | KDR (0.47) | SMOKDRLMNAMEN1KMT2A | |
| SCHEMBL4737638 | 0.79 | KDR (0.55) | KDRLMNAGAAMEN1KMT2A | |
| SCHEMBL14148490 | 0.78 | RXFP1 (0.53) | SMOKDRLMNAGAARXFP1 | |
| SCHEMBL4741743 | 0.78 | ADCY1 (0.65) | LMNAGAAKCNK3PTGS1ALDH1A1 | |
| SCHEMBL14148837 | 0.78 | KMT2A (0.60) | KDRLMNAMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |