Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 3/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11929486 | 0.93 | ATR (0.43) | ATRALDH1A1CHEK1ACHECDK1 | |
| SCHEMBL11929481 | 0.89 | ATR (0.47) | ATRCHEK1ACHECDK1CDK4 | |
| SCHEMBL11929488 | 0.89 | ATR (0.47) | ATRCHEK1ACHECDK1CDK4 | |
| SCHEMBL11908594 | 0.88 | DYRK1A (0.43) | WNT1DYRK1ACHEK1ACHEPIM1 | |
| SCHEMBL11909375 | 0.84 | DYRK1A (0.53) | ATRWNT1DYRK1ACHEK1ACHE | |
| SCHEMBL473759 | 0.84 | ATR (0.41) | ATRCHEK1ACHECDK1CDK4 | |
| SCHEMBL3723614 | 0.83 | CHEK1 (0.39) | WNT1DYRK1ACHEK1ACHEPIM1 | |
| SCHEMBL11908845 | 0.81 | RIPK1 (0.46) | WNT1DYRK1ACHEK1ACHECDK2 | |
| SCHEMBL473748 | 0.81 | CHEK1 (0.44) | CHEK1ACHE | |
| SCHEMBL11929463 | 0.81 | RIPK1 (0.49) | ATRCHEK1ACHECDK2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411389-A2 | 9H-PYRROLO[2,3-B: 5,4-C']DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-01 | — | — | EP | claimed |
| WO-2010109084-A2 | 9H-PYRROLO[2,3-B: 5,4-C'] DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | claimed |