Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 11/20 | 0.41 |
| ▸ | CDK1 | P06493 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11929481 | 0.92 | ATR (0.47) | ATRCDK1CDK2PDE4BCDK4 | |
| SCHEMBL11929488 | 0.92 | ATR (0.47) | ATRCDK1CDK2PDE4BCDK4 | |
| SCHEMBL11929487 | 0.89 | ALDH1A1 (0.39) | CHEK1ACHE | |
| SCHEMBL11929486 | 0.88 | ATR (0.43) | ATRCDK1CDK2PDE4BCDK4 | |
| SCHEMBL473780 | 0.84 | ATR (0.39) | ATRCDK1CDK2PDE4BCDK4 | |
| SCHEMBL13190687 | 0.81 | PIM1 (0.48) | CHEK1ACHE | |
| SCHEMBL3723614 | 0.80 | CHEK1 (0.39) | CHEK1ACHE | |
| SCHEMBL11908018 | 0.79 | PIM1 (0.45) | CHEK1ACHE | |
| SCHEMBL11929463 | 0.78 | RIPK1 (0.49) | ATRCDK2CHEK1ACHE | |
| SCHEMBL473656 | 0.77 | DYRK1A (0.46) | CDK1TLR9TLR8TLR7CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411389-A2 | 9H-PYRROLO[2,3-B: 5,4-C']DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010109084-A2 | 9H-PYRROLO[2,3-B: 5,4-C'] DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | disclosed |