Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | APLNR | P35414 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737869 | 0.84 | ALDH1A1 (0.45) | GSK3BALDH1A1HPGDSMN1; SMN2ALOX12 | |
| SCHEMBL4741835 | 0.76 | LMNA (0.51) | GSK3BALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL4738614 | 0.71 | GSK3B (0.46) | GSK3BALDH1A1SMN1; SMN2KDM4EHTT | |
| SCHEMBL4739125 | 0.70 | GSK3B (0.51) | GSK3BAPLNRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4739999 | 0.70 | LMNA (0.45) | GSK3BALDH1A1SMN1; SMN2KDM4EHTT | |
| SCHEMBL4739176 | 0.67 | TSHR (0.50) | APLNRALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL3521617 | 0.64 | ALDH1A1 (0.51) | ALDH1A1HPGDSMN1; SMN2KDM4ELMNA | |
| SCHEMBL11367386 | 0.63 | ALDH1A1 (0.55) | ALDH1A1HPGDSMN1; SMN2ALOX12KDM4E | |
| SCHEMBL4871162 | 0.61 | IDO1 (0.55) | LMNAMEN1KMT2ATDP1ADRA2A | |
| SCHEMBL4739122 | 0.61 | KMT2A (0.47) | GSK3BALDH1A1HPGDSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089051-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES: PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |