Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 8/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8179569 | 0.85 | PDK1 (0.43) | MAPK14CXCR2PDK1 | |
| SCHEMBL3823781 | 0.84 | PDK1 (0.46) | MAPK14CXCR2PDK1 | |
| SCHEMBL3055944 | 0.82 | CXCR1 (0.42) | MAPK14CXCR2PDK1CYP3A4 | |
| SCHEMBL3824063 | 0.82 | PDK1 (0.48) | GAATSHRMAPK14PDK1 | |
| SCHEMBL4737592 | 0.81 | GAA (0.56) | GAATSHRHTTMAPK14PTGDR2 | |
| SCHEMBL4737107 | 0.81 | GAA (0.58) | GAATSHRHTTMAPK14PTGDR2 | |
| SCHEMBL3061759 | 0.80 | TRPV1 (0.41) | CXCR2POLBCYP3A4 | |
| SCHEMBL4734186 | 0.79 | GRM1 (0.45) | GAATSHRHTTMAPK14CXCR2 | |
| SCHEMBL4738966 | 0.79 | GAA (0.54) | GAATSHRHTTMAPK14PTGDR2 | |
| SCHEMBL4737668 | 0.79 | GAA (0.56) | GAATSHRHTTMAPK14PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |