Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | DUT | P33316 | 2/20 | 0.36 |
| ▸ | PSMD10 | O75832 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20294716 | 0.97 | CA12 (0.40) | CA12CA1CA9ALDH1A1DUT | |
| SCHEMBL29704301 | 0.94 | ALDH1A1 (0.38) | CA12CA1CA9ALDH1A1DUT | |
| SCHEMBL2721499 | 0.93 | CA12 (0.42) | CA12CA1CA9ALDH1A1DUT | |
| SCHEMBL17185826 | 0.93 | CA12 (0.42) | CA12CA1CA9ALDH1A1DUT | |
| SCHEMBL23364467 | 0.93 | CA12 (0.42) | CA12CA1CA9ALDH1A1DUT | |
| SCHEMBL23611465 | 0.93 | CA12 (0.42) | CA12CA1CA9ALDH1A1DUT | |
| SCHEMBL25390430 | 0.93 | CA12 (0.42) | CA12CA1CA9ALDH1A1DUT | |
| SCHEMBL5854114 | 0.92 | CA12 (0.40) | CA12CA1CA9ALDH1A1DUT | |
| SCHEMBL2244693 | 0.91 | CA12 (0.39) | CA12CA1CA9ALDH1A1DUT | |
| SCHEMBL2251597 | 0.89 | CA12 (0.40) | CA12CA1CA9ALDH1A1DUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075152-A1 | 1- [4- (SULFONYL) -PHENYL] -5- (BENZYL) -IH-I, 2, 4-TRIAZOL DERIVATIVES AS INHIBITORS OF CARBONIC ANHYDRASE FOR TREATING GLAUCOMA OR OCULAR HYPERTENSION | PFIZER PRODUCTS INC. (US) | 2008-06-26 | — | — | WO | disclosed |