SCHEMBL473963

SCHEMBL473963

N#Cc1ccc(O)cc1Cl

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 1/20 0.57
HSD17B10 Q99714 1/20 0.52
AR P10275 8/20 0.47
IDO1 P14902 1/20 0.46
TTR P02766 1/20 0.45
CYP11B2 P19099 1/20 0.43
ESR1 P03372 4/20 0.42
ESR2 Q92731 3/20 0.42
CA12 O43570 2/20 0.41
CA2 P00918 2/20 0.41
CA9 Q16790 2/20 0.41
CA14 Q9ULX7 2/20 0.41
CA1 P00915 1/20 0.41
CA7 P43166 1/20 0.41
CA3 P07451 1/20 0.41
CA6 P23280 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10658114 0.82 HSD17B10 (0.52) TRPV4HSD17B10ARTTRESR1
SCHEMBL757008 0.82 AR (0.57) AR
SCHEMBL17672488 0.81 CA9 (0.47) TRPV4HSD17B10ARTTRESR1
SCHEMBL29473510 0.78 CA9 (0.46) ARESR1ESR2CA12CA2
SCHEMBL1697195 0.78 CA9 (0.46) ARESR1ESR2CA12CA2
SCHEMBL10650840 0.77 HSD17B10 (0.52) HSD17B10TTRESR1ESR2CA12
SCHEMBL17672644 0.77 HSD17B10 (0.52) HSD17B10TTRESR1ESR2CA12
SCHEMBL1267080 0.76 ESR2 (0.44) ARESR1ESR2CA12CA2
SCHEMBL101711 0.76 TRPV4 (0.61) TRPV4HSD17B10ARIDO1CYP11B2
SCHEMBL2947436 0.74 TRPV4 (0.59) TRPV4ARIDO1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 521 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-58018351-A None JP disclosed
JP-58018350-A None JP disclosed
JP-58049355-A None JP disclosed
JP-58121266-A None JP disclosed
JP-57142955-A None JP disclosed
JP-57154158-A None JP disclosed
JP-59144747-A None JP disclosed
JP-56016458-A None JP disclosed
JP-61218568-A None JP disclosed
JP-61158954-A None JP disclosed
US-4452719-A LIQUID CRYSTALS CHISSO CORPORATION (JP) 1984-06-05 US disclosed
US-4424371-A LIQUID CRYSTALS TIMEX CORPORATION (US) 1984-01-03 US disclosed
EP-0094198-A2 4-(Trans-4'-alkyloxymethylcyclohexyl) benzoic acid esters Chisso Corporation (JP) 1983-11-16 EP disclosed
JP-S58121266-A 4-(TRANS-4'-ALKYLOXYMETHYLCYCLOHEXYL)BENZOIC ESTER DERIVATIVE CHISSO CORP 1983-07-19 JP disclosed
JP-S5849355-A P-(BETA-ALKYLOXY)ETHYLBENZOIC ACID ESTERS CHISSO CORP 1983-03-23 JP disclosed
JP-S5818351-A LIQUID CRYSTAL COMPOUND SEIKO EPSON CORP 1983-02-02 JP disclosed
JP-S5818350-A LIQUID CRYSTAL COMPOUND SEIKO EPSON CORP 1983-02-02 JP disclosed
JP-S57154158-A LIQUID CRYSTAL SUBSTANCE HAVING LARGE POSITIVE DIELECTRIC ANISOTROPY CHISSO CORP 1982-09-22 JP disclosed
JP-S57142955-A LIQUID CRYSTAL ADDITIVE HAVING HIGH POSITIVE DIELECTRIC ANISOTROPIC VALUE CHISSO CORP 1982-09-03 JP disclosed
JP-S5616458-A ESTER COMPOUND SEIKO EPSON CORP 1981-02-17 JP disclosed