Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 5/20 | 0.44 |
| ▸ | CA1 | P00915 | 5/20 | 0.44 |
| ▸ | CA9 | Q16790 | 5/20 | 0.44 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27957723 | 0.86 | MAPT (0.50) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL5987639 | 0.80 | MAPT (0.45) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL10447991 | 0.80 | MEN1 (0.45) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL23771636 | 0.77 | AGER (0.53) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL22779337 | 0.77 | CA12 (0.44) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL16956424 | 0.77 | NQO1 (0.50) | MAPTMEN1KMT2ASMN1; SMN2CA12 | |
| SCHEMBL5439339 | 0.76 | MAPT (0.45) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL26335081 | 0.76 | MAPT (0.49) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL21736861 | 0.76 | ALDH1A1 (0.49) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL27548816 | 0.76 | MEN1 (0.42) | MAPTMEN1LMNAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343775-B1 | PIPERAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-06-04 | — | — | EP | claimed |