Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | GPR6 | P46095 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | PLK1 | P53350 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | STK17B | O94768 | 1/20 | 0.37 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14148423 | 0.92 | CCNA2 (0.47) | CCNA2CDK2EGFRPLK1MAPT | |
| Trifluoroacetic Acid SCHEMBL4740268 | 0.85 | GPR6 (0.41) | CCNA2CDK2GPR6GRIK1KCNMA1 | |
| SCHEMBL14148144 | 0.76 | CCNA2 (0.41) | CCNA2CDK2HTR2AHTR2CEGFR | |
| SCHEMBL4739024 | 0.76 | ADORA1 (0.50) | CCNA2CDK2EGFRTP53ADORA2A | |
| SCHEMBL14148146 | 0.75 | ADORA2A (0.48) | CCNA2CDK2EGFRKDRTP53 | |
| SCHEMBL14148145 | 0.74 | MAPT (0.50) | CCNA2CDK2EGFRPLK1MEN1 | |
| Trifluoroacetic Acid SCHEMBL4742391 | 0.72 | TYMS (0.45) | ADORA2A | |
| SCHEMBL4739911 | 0.69 | TYMS (0.52) | ADORA2AADORA2B | |
| SCHEMBL4739906 | 0.63 | TYMS (0.49) | CCNA2CDK2EGFRPLK1KDR | |
| SCHEMBL4787500 | 0.61 | TYMS (0.50) | ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |