Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL753721 | 0.88 | HPGD (0.47) | CHEK1CHEK2HDAC1RAF1BRAF | |
| SCHEMBL13304547 | 0.83 | CHEK1 (0.48) | CHEK1CHEK2HDAC6HDAC3HDAC4 | |
| SCHEMBL1010636 | 0.81 | ACACB (0.45) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL753771 | 0.81 | CHEK1 (0.58) | CHEK1CHEK2HDAC6HDAC3HDAC4 | |
| SCHEMBL13538787 | 0.80 | HDAC6 (0.47) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13304515 | 0.79 | CHEK1 (0.43) | CHEK1CHEK2HDAC6HDAC3HDAC4 | |
| SCHEMBL13538789 | 0.79 | P2RY12 (0.46) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4740157 | 0.79 | CHEK1 (0.73) | CHEK1CHEK2MAPTL3MBTL1KDM4E | |
| SCHEMBL4740317 | 0.77 | CHEK1 (0.53) | CHEK1CHEK2RAF1BRAFCKS1B | |
| SCHEMBL20552595 | 0.77 | OGA (0.44) | HDAC3HDAC1HDAC2HDAC8ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8377935-B2 | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-02-19 | — | — | US | disclosed |
| US-20120157456-A1 | SUBSTITUTED AMINOPROPENYL PIPERIDINE OR MORPHOLINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-06-21 | — | — | US | disclosed |
| US-8138198-B2 | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase | ANGIBAUD PATRICK RENE (FR) | 2012-03-20 | — | — | US | disclosed |
| US-7834011-B2 | Heterocyclylalkyl derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-11-16 | — | — | US | disclosed |
| US-7834011-B2 | Heterocyclylalkyl derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-11-16 | — | — | US | disclosed |
| US-20100160321-A1 | IMIDAZOLINONE AND HYDANTOINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-06-24 | — | — | US | disclosed |
| US-20100160321-A1 | IMIDAZOLINONE AND HYDANTOINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-06-24 | — | — | US | disclosed |
| US-20090221580-A1 | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase | ANGIBAUD PATRICK RENE | 2009-09-03 | — | — | US | disclosed |
| US-20090221580-A1 | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase | ANGIBAUD PATRICK RENE | 2009-09-03 | — | — | US | disclosed |
| US-20090023726-A1 | Heterocyclylalkyl Derivatives as Novel Inhibitors of Histone Deacetylase | JANSSEN-CILAG (FR) | 2009-01-22 | — | — | US | disclosed |
| US-20090023726-A1 | Heterocyclylalkyl Derivatives as Novel Inhibitors of Histone Deacetylase | JANSSEN-CILAG (FR) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221580-A1 | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase | HDAC1, HDAC2, HDAC3 | CHEK1 1813/4885CHEK2 725/4885HDAC6 10/4885 |
| US-20120157456-A1 | SUBSTITUTED AMINOPROPENYL PIPERIDINE OR MORPHOLINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC2, HDAC3 | CHEK1 1813/4885CHEK2 725/4885HDAC6 10/4885 |
| US-20100160321-A1 | IMIDAZOLINONE AND HYDANTOINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC2, HDAC3 | CHEK1 845/4885CHEK2 477/4885HDAC6 11/4885 |
| US-20090023726-A1 | Heterocyclylalkyl Derivatives as Novel Inhibitors of Histone Deacetylase | HDAC1, HDAC11, HDAC3 | CHEK1 965/4885CHEK2 640/4885HDAC6 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.