Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | S100B | P04271 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | TPMT | P51580 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5679214 | 0.97 | ALDH1A1 (0.37) | ALDH1A1TSHRMAPTKDM4EMEN1 | |
| SCHEMBL7092582 | 0.85 | ALDH1A1 (0.38) | ALDH1A1TSHRMAPTKDM4EMEN1 | |
| SCHEMBL16659632 | 0.80 | ALDH1A1 (0.37) | ALDH1A1TSHRMAPTKDM4EMEN1 | |
| SCHEMBL27965052 | 0.78 | ALDH1A1 (0.41) | ALDH1A1TSHRMAPTKDM4EMEN1 | |
| SCHEMBL10815192 | 0.71 | ALDH1A1 (0.44) | ALDH1A1TSHRMAPTMEN1KMT2A | |
| SCHEMBL1672267 | 0.71 | ALDH1A1 (0.44) | ALDH1A1TSHRHSP90AA1BLMACHE | |
| SCHEMBL11695348 | 0.71 | ALDH1A1 (0.44) | ALDH1A1TSHRMAPTMEN1KMT2A | |
| SCHEMBL3740737 | 0.71 | KMT2A (0.37) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL3740739 | 0.71 | KMT2A (0.37) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL14816948 | 0.71 | CYP2D6 (0.56) | ALDH1A1MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8361922-B2 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | MATERIA, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-8361922-B2 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | MATERIA, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-20120123133-A1 | ORGANOMETALLIC RUTHENIUM COMPLEXES AND RELATED METHODS FOR THE PREPARATION OF TETRA-SUBSTITUTED AND OTHER HINDERED OLEFINS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120123133-A1 | ORGANOMETALLIC RUTHENIUM COMPLEXES AND RELATED METHODS FOR THE PREPARATION OF TETRA-SUBSTITUTED AND OTHER HINDERED OLEFINS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2012-05-17 | — | — | US | disclosed |
| US-8008224-B2 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | MATERIA, INC. (US) | 2011-08-30 | — | — | US | disclosed |
| US-8008224-B2 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | MATERIA, INC. (US) | 2011-08-30 | — | — | US | disclosed |
| US-20070282148-A1 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2007-12-06 | — | — | US | disclosed |
| US-20070282148-A1 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2007-12-06 | — | — | US | disclosed |
| WO-2007075427-A1 | ORGANOMETALLIC RUTHENIUM COMPLEXES AND RELATED METHODS FOR THE PREPARATION OF TETRA-SUBSTITUTED AND OTHER HINDERED OLEFINS | MATERIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120123133-A1 | ORGANOMETALLIC RUTHENIUM COMPLEXES AND RELATED METHODS FOR THE PREPARATION OF TETRA-SUBSTITUTED AND OTHER HINDERED OLEFINS | ORC3, OXER1, CBR3 | ALDH1A1 2951/4885TSHR 2215/4885MAPT 2228/4885 |
| US-20070282148-A1 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | ORC3, OXER1, CBR3 | ALDH1A1 2951/4885TSHR 2215/4885MAPT 2228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.