Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.62 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740502 | 1.00 | MAPT (0.62) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL4740529 | 0.90 | MAPT (0.67) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL4740526 | 0.90 | MAPT (0.67) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL4740506 | 0.89 | ALDH1A1 (0.52) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL4740490 | 0.89 | ALDH1A1 (0.52) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL4738828 | 0.83 | MAPT (0.63) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL4738825 | 0.83 | MAPT (0.63) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL4740739 | 0.81 | ALDH1A1 (0.59) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL4740738 | 0.81 | ALDH1A1 (0.59) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL14146446 | 0.80 | MAPT (0.48) | MAPTALDH1A1LMNASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087367-A2 | SUBSTITUTED (PHENYLTHIAZOLYL)-PHENYL-PROPAN-1-ONE AND (PHENYLOXAZODYL)-PHENYL-PROPAN-1-ONE DERIVATIVES, PREPARATIONS AND USES OF SAME | GENFIT (FR) | 2008-07-24 | — | — | WO | disclosed |