Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740526 | 1.00 | MAPT (0.67) | MAPTSMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL4740502 | 0.90 | MAPT (0.62) | MAPTSMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL4740504 | 0.90 | MAPT (0.62) | MAPTSMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL4740506 | 0.86 | ALDH1A1 (0.52) | MAPTSMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL4740490 | 0.86 | ALDH1A1 (0.52) | MAPTSMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL4738825 | 0.80 | MAPT (0.63) | MAPTSMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL4738828 | 0.80 | MAPT (0.63) | MAPTSMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL4740739 | 0.79 | ALDH1A1 (0.59) | MAPTSMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL4740738 | 0.79 | ALDH1A1 (0.59) | MAPTSMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL14146446 | 0.78 | MAPT (0.48) | MAPTSMN1; SMN2ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087367-A2 | SUBSTITUTED (PHENYLTHIAZOLYL)-PHENYL-PROPAN-1-ONE AND (PHENYLOXAZODYL)-PHENYL-PROPAN-1-ONE DERIVATIVES, PREPARATIONS AND USES OF SAME | GENFIT (FR) | 2008-07-24 | — | — | WO | disclosed |