Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 5/20 | 0.36 |
| ▸ | ABCC9 | O60706 | 7/20 | 0.35 |
| ▸ | ABCC8 | Q09428 | 7/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 7/20 | 0.35 |
| ▸ | KCNJ8 | Q15842 | 7/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740558 | 0.95 | CNR1 (0.35) | BACE1CTSDBACE2CNR1ABCC9 | |
| SCHEMBL4738375 | 0.86 | CNR1 (0.34) | CNR1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL4738661 | 0.85 | PKM (0.38) | BACE1CNR1 | |
| SCHEMBL4511507 | 0.85 | BACE1 (0.42) | BACE1CTSDBACE2CNR1CSNK2A2 | |
| SCHEMBL4520613 | 0.84 | BACE1 (0.43) | BACE1CTSDBACE2CNR1CSNK2A2 | |
| SCHEMBL4734518 | 0.83 | CNR1 (0.35) | BACE1CTSDCNR1ABCC9ABCC8 | |
| SCHEMBL4786160 | 0.81 | CNR1 (0.38) | BACE1CNR1ABCC9ABCC8KCNJ11 | |
| SCHEMBL4785590 | 0.81 | CNR1 (0.38) | BACE1CNR1 | |
| SCHEMBL4517752 | 0.80 | CNR1 (0.38) | BACE1CTSDBACE2CNR1CLK1 | |
| SCHEMBL4732724 | 0.80 | CNR1 (0.47) | CNR1ABCC9ABCC8KCNJ11KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076043-A1 | NOVEL 2-AMINO-5,5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076043-A1 | NOVEL 2-AMINO-5,5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |