Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972770 | 0.84 | TDP2 (0.52) | MAPK1MEN1KMT2ALMNAKDM4E | |
| SCHEMBL4973505 | 0.83 | KDM4E (0.46) | MEN1KMT2ALMNAKDM4EMAPT | |
| SCHEMBL4974228 | 0.82 | MEN1 (0.41) | MEN1KMT2ALMNAKDM4EMAPT | |
| SCHEMBL4970905 | 0.81 | ATM (0.43) | MEN1KMT2A | |
| SCHEMBL4970874 | 0.81 | GRM5 (0.39) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL4969649 | 0.80 | HPGD (0.43) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL4972012 | 0.79 | ALDH1A1 (0.41) | MAPK1MEN1KMT2ALMNAKDM4E | |
| SCHEMBL4970522 | 0.77 | HRH3 (0.40) | GAA | |
| SCHEMBL23386544 | 0.76 | MAPK1 (0.40) | MAPK1SLC6A15DPP4MEN1KMT2A | |
| SCHEMBL8055202 | 0.76 | MEN1 (0.42) | MAPK1SLC6A15DPP4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |