Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 7/20 | 0.85 |
| ▸ | DBF4 | Q9UBU7 | 7/20 | 0.85 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.85 |
| ▸ | CDK2 | P24941 | 2/20 | 0.85 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RARA | P10276 | 1/20 | 0.51 |
| ▸ | RARB | P10826 | 1/20 | 0.51 |
| ▸ | RARG | P13631 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL974859 | 0.86 | CDC7 (0.84) | CDC7DBF4CCNE1CDK2PTGDR2 | |
| SCHEMBL9635836 | 0.83 | CDC7 (0.61) | CDC7DBF4CCNE1CDK2SMN1; SMN2 | |
| SCHEMBL3056066 | 0.83 | CDC7 (0.65) | CDC7DBF4CCNE1CDK2PTGDR2 | |
| SCHEMBL956697 | 0.83 | CDC7 (0.61) | CDC7DBF4CCNE1CDK2KDM4E | |
| SCHEMBL2521905 | 0.83 | ALDH1A1 (0.62) | CDC7DBF4CCNE1CDK2KDM4E | |
| SCHEMBL954078 | 0.82 | CDC7 (0.68) | CDC7DBF4CCNE1CDK2PTGDR2 | |
| SCHEMBL4243016 | 0.81 | SMN1; SMN2 (0.76) | CDC7DBF4CCNE1CDK2KDM4E | |
| SCHEMBL15064348 | 0.80 | CDC7 (0.62) | CDC7DBF4CCNE1CDK2PTGDR2 | |
| SCHEMBL30511202 | 0.80 | CDC7 (0.58) | CDC7DBF4CCNE1CDK2PTGDR2 | |
| SCHEMBL975727 | 0.80 | CDC7 (0.86) | CDC7DBF4CCNE1CDK2PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |