Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 10/20 | 0.62 |
| ▸ | DBF4 | Q9UBU7 | 10/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.62 |
| ▸ | CDK2 | P24941 | 2/20 | 0.62 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28544975 | 0.84 | CDC7 (0.53) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL4740819 | 0.80 | CDC7 (0.85) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL15064378 | 0.80 | HPGDS (0.45) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL17054245 | 0.77 | RARA (0.49) | CDC7DBF4MEN1KMT2AALDH1A1 | |
| SCHEMBL954078 | 0.76 | CDC7 (0.68) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL17051059 | 0.74 | HPGDS (0.42) | CDC7DBF4ALDH1A1KDM4EHPGDS | |
| SCHEMBL15064349 | 0.74 | KDM4E (0.44) | CDC7DBF4ALDH1A1KDM4EHPGDS | |
| SCHEMBL953158 | 0.72 | CDC7 (0.56) | CDC7DBF4CCNE1CDK2MEN1 | |
| SCHEMBL953404 | 0.72 | CDC7 (0.55) | CDC7DBF4CCNE1CDK2 | |
| SCHEMBL953055 | 0.72 | CDC7 (0.61) | CDC7DBF4CCNE1CDK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11963994-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2024-04-23 | — | — | US | claimed |
| US-20220211797-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2022-07-07 | — | — | US | claimed |
| CN-107915728-B | IAP inhibitors | 库里斯公司 | 2021-04-30 | — | — | CN | claimed |
| US-20190224269-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2019-07-25 | — | — | US | claimed |
| EP-3133073-B1 | INHIBITORS OF IAP | CURIS INC (US) | 2018-05-02 | — | — | EP | claimed |
| US-20170136084-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2017-05-18 | — | — | US | claimed |
| US-9586991-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2017-03-07 | — | — | US | claimed |
| EP-3133073-A2 | INHIBITORS OF IAP | Curis, Inc. (US) | 2017-02-22 | — | — | EP | claimed |
| EP-2800749-B1 | INHIBITORS OF IAP | CURIS INC (US) | 2016-09-21 | — | — | EP | claimed |
| US-20160102119-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2016-04-14 | — | — | US | claimed |
| US-9238675-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2016-01-19 | — | — | US | claimed |
| EP-2800749-A1 | INHIBITORS OF IAP | Curis, Inc. (US) | 2014-11-12 | — | — | EP | claimed |
| US-8716236-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2014-05-06 | — | — | US | claimed |
| WO-2013103703-A1 | INHIBITORS OF IAP | CURIS, INC. (US) | 2013-07-11 | — | — | WO | claimed |
| US-20130172264-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2013-07-04 | — | — | US | claimed |
| US-11963994-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2024-04-23 | — | — | US | disclosed |
| US-20220211797-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2022-07-07 | — | — | US | disclosed |
| US-8716236-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2014-05-06 | — | — | US | disclosed |
| WO-2013103703-A1 | INHIBITORS OF IAP | CURIS, INC. (US) | 2013-07-11 | — | — | WO | disclosed |
| US-20130172264-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2013-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170136084-A1 | INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | CDC7 795/4885DBF4 1788/4885CCNE1 570/4885 |
| US-20190224269-A1 | INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | CDC7 795/4885DBF4 1788/4885CCNE1 570/4885 |
| US-20130172264-A1 | INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | CDC7 795/4885DBF4 1788/4885CCNE1 570/4885 |
| US-20160102119-A1 | INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | CDC7 795/4885DBF4 1788/4885CCNE1 570/4885 |
| US-20220211797-A1 | INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | CDC7 795/4885DBF4 1788/4885CCNE1 570/4885 |
| US-11963994-B2 | Inhibitors of IAP | BIRC5, XIAP, BIRC3 | CDC7 795/4885DBF4 1788/4885CCNE1 570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.