Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743431 | 0.87 | MAPK1 (0.40) | MAPK1MAPTL3MBTL1ABCG2HTT | |
| SCHEMBL4740295 | 0.87 | PTGS1 (0.40) | MAPK1PTGS1MAPTABCG2PRKCI | |
| SCHEMBL4740942 | 0.84 | PTGS1 (0.46) | PTGS1MAPTL3MBTL1ABCG2HTT | |
| SCHEMBL4740291 | 0.84 | PTGS1 (0.46) | PTGS1MAPTL3MBTL1ABCG2HTT | |
| SCHEMBL14103888 | 0.83 | PIK3CA (0.37) | MAPK1PTGS1MAPTL3MBTL1ABCG2 | |
| SCHEMBL14104167 | 0.83 | KDM4E (0.35) | MAPK1PTGS1MAPTPRKCICYP2C9 | |
| SCHEMBL14103767 | 0.82 | HTT (0.43) | MAPTABCG2HTTCYP2C9CYP2C19 | |
| SCHEMBL4573992 | 0.82 | MAPK1 (0.44) | MAPK1MAPTABCG2PRKCIPDE4B | |
| SCHEMBL4783849 | 0.81 | MAPT (0.49) | MAPTL3MBTL1ABCG2HTTPDE4B | |
| SCHEMBL14104079 | 0.80 | CYP1A2 (0.36) | MAPK1MAPTABCG2HRH4PRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092861-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | claimed |
| WO-2008092861-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |