SCHEMBL4741168

SCHEMBL4741168

CC(C)(C)[SiH2]OC(C)(C)c1nc2cc(C(=O)O)ccc2[nH]1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.47
TDP1 Q9NUW8 2/20 0.41
HSP90AA1 P07900 1/20 0.41
ESR2 Q92731 1/20 0.41
HRH3 Q9Y5N1 1/20 0.39
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 2/20 0.39
THRB P10828 1/20 0.39
HPGD P15428 1/20 0.39
HCAR3 P49019 2/20 0.39
LMNA P02545 1/20 0.38
HTT P42858 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
B3GNT2 Q9NY97 1/20 0.38
AURKA O14965 2/20 0.37
KIF11 P52732 1/20 0.37
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22487928 0.81 SMN1; SMN2 (0.56) SMN1; SMN2TDP1HSP90AA1ESR2HRH3
SCHEMBL4739312 0.79 CYP2A6 (0.34) SMN1; SMN2ALDH1A1L3MBTL1KIF11
SCHEMBL4744101 0.79 SCN10A (0.35)
SCHEMBL31695181 0.76 SMN1; SMN2 (0.51) SMN1; SMN2TDP1HSP90AA1ESR2HRH3
SCHEMBL2923502 0.76 SMN1; SMN2 (0.78) SMN1; SMN2TDP1HSP90AA1ESR2KDM4E
SCHEMBL23280152 0.71 SMN1; SMN2 (0.49) SMN1; SMN2KDM4EALDH1A1LMNAHTT
SCHEMBL24602846 0.70 TDP1 (0.47) SMN1; SMN2TDP1HSP90AA1ESR2HRH3
SCHEMBL1106071 0.70 TDP1 (0.76) SMN1; SMN2TDP1HSP90AA1ESR2HRH3
SCHEMBL766092 0.70 TDP1 (0.49) SMN1; SMN2TDP1HSP90AA1ESR2HRH3
SCHEMBL6472733 0.70 TDP1 (0.44) SMN1; SMN2TDP1HSP90AA1ESR2HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008096129-A1 NITROGEN CONTAINING HETROCYCLIC COMPOUNDS USEFUL AS BIFUNCTIONAL MODULATORS OF M3 RECEPTORS AND BETA- 2 RECEPTORS ARGENTA DISCOVERY LTD (GB) 2008-08-14 WO disclosed