SCHEMBL4744101

SCHEMBL4744101

CC(C)(C)[SiH2]OC(C)(C)c1nc2cc(CO)ccc2[nH]1

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SCN10A Q9Y5Y9 2/20 0.35
HSD17B10 Q99714 1/20 0.34
CBFB Q13951 5/20 0.33
KCNH2 Q12809 1/20 0.33
PRCP P42785 1/20 0.31
MAOA P21397 1/20 0.30
DYRK1A Q13627 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4741168 0.79 SMN1; SMN2 (0.47)
SCHEMBL4739312 0.77 CYP2A6 (0.34) SCN10AKCNH2
SCHEMBL9619825 0.75 NPSR1 (0.53) SCN10AHSD17B10CBFB
SCHEMBL6324712 0.70 HSD17B10 (0.40) HSD17B10CBFBMAOADYRK1A
SCHEMBL889001 0.70 HSD17B10 (0.47) HSD17B10CBFBMAOADYRK1A
Hydrochloric Acid SCHEMBL11366200 0.68 HSD17B10 (0.46) HSD17B10CBFBMAOADYRK1A
SCHEMBL13375046 0.68 HSD17B10 (0.40) HSD17B10CBFBMAOADYRK1A
SCHEMBL11372794 0.67 DDAH1 (0.54) HSD17B10CBFB
SCHEMBL868599 0.67 SMN1; SMN2 (0.43) SCN10AKCNH2
SCHEMBL10955417 0.67 TDP1 (0.41) HSD17B10CBFB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008096129-A1 NITROGEN CONTAINING HETROCYCLIC COMPOUNDS USEFUL AS BIFUNCTIONAL MODULATORS OF M3 RECEPTORS AND BETA- 2 RECEPTORS ARGENTA DISCOVERY LTD (GB) 2008-08-14 WO disclosed