Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 15/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739918 | 0.78 | SGK1 (0.51) | PIK3CANPC1RAB9A | |
| SCHEMBL12979215 | 0.76 | MAPK1 (0.49) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL14506637 | 0.76 | PIK3CA (0.50) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL4679525 | 0.76 | MAPK1 (0.60) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL12979085 | 0.76 | MAPK1 (0.47) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL12979727 | 0.76 | MAPK1 (0.49) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL12985591 | 0.75 | MAPK1 (0.48) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL4353236 | 0.75 | MAPK1 (0.68) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL4738229 | 0.75 | MAPK1 (0.51) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL4739833 | 0.73 | MAPK1 (0.51) | MAPK1PIK3CAMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962854-B1 | PYRIDOPYRAZINE DERIVATIVES AND USE THEREOF AS MODULATORS OF THE SIGNAL TRANSDUCTION PATHS | TERNA ZENTARIS GMBH (DE) | 2015-05-06 | — | — | EP | claimed |
| EP-1636228-B1 | NOVEL PYRIDOPYRAZINES AND USE THEREOF AS KINASE MODULATORS | AETERNA ZENTARIS GMBH (DE) | 2008-10-22 | — | — | EP | claimed |
| US-8937068-B2 | Pyridopyrazine derivatives and their use | ZENTARIS GMBH (DE) | 2015-01-20 | — | — | US | disclosed |
| US-20070123494-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | ZENTARIS GMBH (DE) | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123494-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | PLPBP, PDXK, MAP4K2 | MAPK1 58/4885PIK3CA 866/4885MAPK8 116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.