Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.47 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.43 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.43 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.43 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29410752 | 0.85 | CHRNB4 (0.47) | CHRNB2CHRNA4CHRNA3CHRNB4UCHL1 | |
| SCHEMBL6582599 | 0.85 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNA3CHRNB4ALOX5AP | |
| SCHEMBL29039401 | 0.85 | CHRNB4 (0.47) | CHRNB2CHRNA4CHRNA3CHRNB4UCHL1 | |
| SCHEMBL26999489 | 0.85 | CHRNB4 (0.47) | CHRNB2CHRNA4CHRNA3CHRNB4UCHL1 | |
| SCHEMBL2495176 | 0.85 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNA3CHRNB4UCHL1 | |
| SCHEMBL7370320 | 0.85 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA3CHRNB4ALOX5AP | |
| SCHEMBL1241249 | 0.85 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA3CHRNB4ALOX5AP | |
| SCHEMBL6587123 | 0.85 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNA3CHRNB4UCHL1 | |
| SCHEMBL1241247 | 0.85 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA3CHRNB4ALOX5AP | |
| SCHEMBL14941814 | 0.85 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA3CHRNB4ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
| WO-2008109613-A1 | BENZO[C][2,7]NAPHTHYRIDINE DERIVATIVES, AND THEIR USE AS KINASE INHIBITORS | WYETH (US) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | PDPK1, PDK2, PDK3 | CHRNB2 2779/4885CHRNA4 2092/4885CHRNA3 2363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.