Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14147955 | 0.84 | ADORA2A (0.46) | KMT2AMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL14147958 | 0.84 | SMN1; SMN2 (0.42) | KMT2AMAPK1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL4739051 | 0.84 | ADORA2A (0.48) | KMT2AMEN1MAPTMAPK1POLB | |
| SCHEMBL14147954 | 0.83 | ADORA2A (0.39) | KMT2AMEN1MAPTKDM4EALDH1A1 | |
| SCHEMBL4741116 | 0.83 | DHFR (0.40) | TYMSADORA2AADORA1IKBKBCHUK | |
| SCHEMBL4737498 | 0.82 | PI4KA (0.39) | KMT2AMEN1MAPTMAPK1MMP14 | |
| SCHEMBL14147959 | 0.80 | MAPT (0.43) | KMT2AMEN1MAPTMAPK1POLB | |
| SCHEMBL14147957 | 0.80 | ADORA2A (0.42) | KMT2AMEN1MAPTGAAKDM4E | |
| SCHEMBL14148134 | 0.80 | L3MBTL1 (0.45) | KMT2AMEN1MAPTGAAKDM4E | |
| SCHEMBL14147950 | 0.79 | MEN1 (0.40) | KMT2AMEN1MAPTGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |