Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4742177 | 0.98 | MBTD1 (0.42) | MBTD1L3MBTL3IDO1OPRM1OPRD1 | |
| SCHEMBL4734690 | 0.95 | MBTD1 (0.42) | MBTD1L3MBTL3IDO1OPRM1OPRD1 | |
| SCHEMBL4520767 | 0.91 | OPRM1 (0.43) | MBTD1L3MBTL3IDO1OPRM1OPRD1 | |
| SCHEMBL1419783 | 0.91 | OPRM1 (0.43) | MBTD1L3MBTL3IDO1OPRM1OPRD1 | |
| SCHEMBL18706778 | 0.83 | SLC18A3 (0.43) | MBTD1L3MBTL3IDO1MEN1KMT2A | |
| SCHEMBL18706553 | 0.81 | SLC18A3 (0.44) | MBTD1L3MBTL3IDO1TDO2MEN1 | |
| SCHEMBL11341778 | 0.81 | OPRL1 (0.55) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL27336292 | 0.79 | MBTD1 (0.48) | MBTD1L3MBTL3IDO1 | |
| SCHEMBL30747365 | 0.79 | OPRL1 (0.56) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL26648907 | 0.79 | OPRL1 (0.56) | OPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063114-A9 | AMINO- IMIDAZOLONES AND THEIR USE AS MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2008-09-04 | — | — | WO | disclosed |
| WO-2008063114-A9 | AMINO- IMIDAZOLONES AND THEIR USE AS MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2008-09-04 | — | — | WO | disclosed |
| WO-2008063114-A1 | AMINO- IMIDAZOLONES AND THEIR USE AS MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2008-05-29 | — | — | WO | disclosed |
| WO-2008063114-A1 | AMINO- IMIDAZOLONES AND THEIR USE AS MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2008-05-29 | — | — | WO | disclosed |