Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 3/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 5/20 | 0.36 |
| ▸ | DRD5 | P21918 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4741076 | 0.84 | KMT2A (0.42) | ALDH1A1KMT2AMEN1KDM4EUSP2 | |
| SCHEMBL4739124 | 0.84 | HPGD (0.43) | ALDH1A1KMT2AMEN1KDM4EUSP2 | |
| SCHEMBL4737525 | 0.83 | KMT2A (0.54) | ALDH1A1KMT2AMEN1KDM4EUSP2 | |
| SCHEMBL4740407 | 0.80 | NPC1 (0.50) | KMT2AMEN1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL4741265 | 0.80 | NPC1 (0.50) | KMT2AMEN1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL4784791 | 0.80 | APLNR (0.42) | ALDH1A1KMT2AMEN1KDM4EUSP2 | |
| SCHEMBL17317042 | 0.79 | APLNR (0.51) | ALDH1A1KMT2AMEN1KDM4EUSP2 | |
| SCHEMBL4739114 | 0.79 | NPC1 (0.51) | KMT2AMEN1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL4784797 | 0.78 | APLNR (0.48) | ALDH1A1KMT2AMEN1KDM4EUSP2 | |
| SCHEMBL4739975 | 0.78 | KMT2A (0.38) | ALDH1A1KMT2AMEN1KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089051-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES: PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |
| US-20080171756-A1 | N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171756-A1 | N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN2, EGLN3 | ALDH1A1 513/4885KMT2A 734/4885MEN1 2935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.