Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4741829 | 0.89 | APLNR (0.50) | APLNRALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL4784791 | 0.82 | APLNR (0.42) | APLNRALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL4739124 | 0.79 | HPGD (0.43) | APLNRALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL4737525 | 0.79 | KMT2A (0.54) | APLNRALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL4739146 | 0.74 | EGLN1 (0.45) | APLNRALDH1A1MAPTPOLBLMNA | |
| SCHEMBL4741828 | 0.74 | APLNR (0.44) | APLNRALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL4739975 | 0.74 | KMT2A (0.38) | APLNRALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL4782896 | 0.73 | KMT2A (0.44) | APLNRALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL4739974 | 0.73 | ALDH1A1 (0.38) | APLNRALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL4740213 | 0.71 | KMT2A (0.42) | APLNRALDH1A1MAPTPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089051-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES: PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |