SCHEMBL4742687

SCHEMBL4742687

O=[N+](O)c1ccccc1CCOP(=O)([O-])O

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.37
TSHR P16473 2/20 0.37
NPC1 O15118 3/20 0.36
RAB9A P51151 3/20 0.36
RECQL P46063 1/20 0.36
HPGD P15428 1/20 0.34
CTSD P07339 1/20 0.33
MAOB P27338 1/20 0.33
HTT P42858 1/20 0.33
KDM4E B2RXH2 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
PTPN1 P18031 1/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2232571 0.84 ALDH1A1 (0.37) ALDH1A1TSHRNPC1RAB9ARECQL
SCHEMBL4742693 0.78 ALDH1A1 (0.50) ALDH1A1TSHRNPC1RAB9ARECQL
SCHEMBL4742682 0.78 ALDH1A1 (0.50) ALDH1A1TSHRNPC1RAB9ARECQL
SCHEMBL4742722 0.74 ALDH1A1 (0.38) ALDH1A1TSHRNPC1RAB9ARECQL
SCHEMBL9482054 0.74 ALDH1A1 (0.49) ALDH1A1TSHRNPC1RAB9ARECQL
SCHEMBL12125185 0.74 ALDH1A1 (0.45) ALDH1A1TSHRNPC1RAB9ARECQL
SCHEMBL735220 0.72 AKR1C3 (0.44) ALDH1A1TSHRNPC1RAB9ASMN1; SMN2
SCHEMBL307101 0.69 ALDH1A1 (0.38) ALDH1A1NPC1RAB9ARECQLHPGD
SCHEMBL9150106 0.69 NPC1 (0.42) ALDH1A1TSHRNPC1RAB9ARECQL
SCHEMBL4747587 0.69 NPC1 (0.42) ALDH1A1TSHRNPC1RAB9ARECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008095007-A1 HOLLOW MICROSPHERES PARTICLES BECKMAN COULTER, INC. (US) 2008-08-07 WO disclosed
EP-1161418-B1 1-ACYL-7-NITROINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHOTOCLEAVABLE PRECURSORS MEDICAL RES COUNCIL (GB) 2005-12-28 EP disclosed
US-6765014-B1 DRUG DELIVERY OF NEUROACTIVE AMINO ACIDS OR METAL CHELATORS MEDICAL RESEARCH COUNCIL (GB) 2004-07-20 US disclosed
EP-1161418-A1 1-ACYL-7-NITROINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHOTOCLEAVABLE PRECURSORS MEDICAL RESEARCH COUNCIL (GB) 2001-12-12 EP disclosed
WO-2000055133-A1 1-ACYL-7-NITROINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHOTOCLEAVABLE PRECURSORS MEDICAL RESEARCH COUNCIL (GB) 2000-09-21 WO disclosed